CIART

Across TCGA pan-cancer cohorts, CIART RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CIART data layer compared with 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher CIART RNA is associated with better overall survival. In most high-consensus cancer types, elevated CIART expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRP show a favorable association.

LUSC, KIRP, and LGG are the cancer types where CIART RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.735	0.613	<.001	72	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.308	.005	49	view →
LGG	OS	Median	All	0.554	0.369	<.001	38	view →
LIHC	OS	Tertile	All	0.683	0.876	<.001	37	view →
ACC	DFS	Median	All	0.441	0.730	.003	29	view →
STAD	DFS	Median	III,IV	0.482	0.667	.010	28	view →
UVM	OS	Median	III,IV	0.876	0.459	.003	25	view →
SCLC	OS	Tertile	III,IV	0.194	0.571	.006	25	view →
KIRC	OS	Quartile	All	0.766	0.588	.001	24	view →
LAML	DFS	Quartile	All	0.305	0.584	.009	24	view →
ESCA	DFS	Median	All	0.904	0.338	.011	18	view →
UCEC	DFS	Median	IV	0.712	0.284	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CIART–LUSC (OS)

Open the LUSC breakdown →