CIAO1

Across TCGA patient cohorts, CIAO1 mutation is significantly associated with the RNA expression of many other genes, with 253 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIAO1-associated genes across cancer lineages are RN7SL248P, GSTA6P, and NTF6G. Each is linked with CIAO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CIAO1-to-partner and partner-to-CIAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by CIAO1-low versus CIAO1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO1→partner) and Y-score (partner→CIAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL248P →	+0.289	+6.618	<.001	.001	3	4
CESC	GSTA6P →	+0.093	+5.010	.001	.009	3	2
CESC	NTF6G →	+0.093	+6.342	<.001	.001	3	2
SKCM	BMP7-AS1 →	+0.089	+5.080	<.001	.004	3	1
SKCM	RNU7-176P →	+0.466	+5.080	<.001	.004	3	1
SKCM	POM121L7P →	+0.036	+4.801	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 253 associations by consensus.

RN7SL248P by CIAO1 expression — BLCA

Explore this box plot interactively →