CHURC1-FNTB

Across TCGA pan-cancer cohorts, CHURC1-FNTB RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CHURC1-FNTB data layer compared with 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHURC1-FNTB RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHURC1-FNTB expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, HNSC, and LGG are the cancer types where CHURC1-FNTB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.738	0.537	<.001	93	view →
HNSC	OS	Quartile	All	0.610	0.750	.008	27	view →
LGG	DFS	Quartile	All	0.900	0.784	<.001	26	view →
SKCM	DFS	Tertile	II,III,IV	0.408	0.218	.002	23	view →
MESO	OS	Median	All	0.767	0.316	.002	21	view →
READ	OS	Tertile	III,IV	0.782	0.972	.005	19	view →
PCPG	OS	Median	All	0.636	1.000	.013	16	view →
LUSC	OS	Quartile	III,IV	0.212	0.476	.012	15	view →
LIHC	OS	Tertile	II,III,IV	0.628	0.390	.013	14	view →
KIRP	DFS	Tertile	All	0.931	0.686	.026	13	view →
BRCA	DFS	Quartile	III,IV	0.691	0.461	.011	13	view →
OV	DFS	Quartile	IV	0.642	0.241	<.001	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CHURC1-FNTB–KIRC (OS)

Open the KIRC breakdown →