CHURC1-FNTB

Across TCGA pan-cancer cohorts, CHURC1-FNTB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CHURC1-FNTB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHURC1-FNTB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHURC1-FNTB is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where CHURC1-FNTB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHURC1-FNTB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.083	<.001	10	view →
THCA	Male	III,IV	−0.128	.001	8	view →
KIRC	Male	All	+0.116	<.001	8	view →
COAD	Male	All	+0.058	.013	3	view →
LUAD	All	IV	+0.114	.016	2	view →
KIRP	All	All	+0.097	.013	2	view →
LUAD	Female	II,III,IV	−0.086	.030	2	view →
UCEC	All	All	−0.074	.007	2	view →
BRCA	All	All	−0.037	.018	2	view →
LUSC	Female	II,III,IV	−0.087	.026	1	view →
LIHC	All	All	+0.015	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

CHURC1-FNTB–HNSC

Open the HNSC breakdown →