Across TCGA patient cohorts, CHUK mutation is significantly associated with the RNA expression of many other genes, with 2,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHUK-associated genes across cancer lineages are MIR4445, MIR6853, and RN7SL248P. Each is linked with CHUK in more than 2 cancer types. Because this analysis shows association rather than direction, both CHUK-to-partner and partner-to-CHUK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHUK→partner) and Y-score (partner→CHUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4445 →	+0.123	+3.893	<.001	.006	3	3
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	2
UCEC	RN7SL248P →	+0.046	+2.783	<.001	.009	3	2
LIHC	RPL22P18 →	+0.405	+4.690	<.001	.003	3	2
CESC	MIR4510 →	+0.300	+5.342	<.001	.002	3	2
COAD	RNU6-1020P →	+0.399	+3.212	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,347 associations by consensus.

Exploration

CHUK survival (RNA) · tumor vs normal (RNA) · all CHUK data types