Across TCGA cell cohorts, CHUK mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHUK-associated genes across cancer lineages are MMP26, SPRR4, and ADAMTS5. Each is linked with CHUK in more than 1 cancer types. Because this analysis shows association rather than direction, both CHUK-to-partner and partner-to-CHUK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHUK→partner) and Y-score (partner→CHUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.028	+2.632	<.001	.002	3	2
LARGE_INTESTINE	SPRR4 →	+0.055	+2.345	.001	.007	3	2
PANCREAS	ADAMTS5 →	+0.006	+3.700	.001	.008	3	1
PANCREAS	SERPINA12 →	+0.010	+4.029	<.001	.007	3	1
PANCREAS	GABRA5 →	+0.042	+4.209	.001	.006	3	1
PANCREAS	OR2A12 →	+0.036	+3.628	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

Exploration

CHUK survival (RNA) · tumor vs normal (RNA) · all CHUK data types