CHTF18

Across TCGA patient cohorts, CHTF18 mutation is significantly associated with the RNA expression of many other genes, with 1,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHTF18-associated genes across cancer lineages are SEC22B2P, CKLF, and LINC01337. Each is linked with CHTF18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHTF18-to-partner and partner-to-CHTF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC22B2P grouped by CHTF18-low versus CHTF18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHTF18→partner) and Y-score (partner→CHTF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEC22B2P →	+0.075	+2.779	<.001	.001	3	3
UCEC	CKLF →	+0.525	+2.818	<.001	.001	3	3
UCEC	LINC01337 →	+0.259	+1.836	.009	.007	3	3
UCEC	ITGAE →	+0.617	+2.754	<.001	<.001	3	3
UCEC	CMC2 →	+0.378	+1.991	<.001	.002	3	3
UCEC	EXOSC9 →	+0.379	+2.871	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,863 associations by consensus.

SEC22B2P by CHTF18 expression — SKCM

Explore this box plot interactively →