Across TCGA patient cohorts, CHSY3 mutation is significantly associated with the RNA expression of many other genes, with 4,654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHSY3-associated genes across cancer lineages are HASPIN, KIF18A, and SNRPA1. Each is linked with CHSY3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHSY3-to-partner and partner-to-CHSY3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHSY3→partner) and Y-score (partner→CHSY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HASPIN →	+0.945	+2.050	<.001	<.001	3	4
UCEC	KIF18A →	+0.578	+1.818	<.001	<.001	3	4
UCEC	SNRPA1 →	+0.435	+2.807	<.001	<.001	3	4
UCEC	RAD54L →	+0.668	+2.086	<.001	<.001	3	4
UCEC	WDR76 →	+0.762	+2.072	<.001	<.001	3	4
BRCA	LDHAP1 →	+0.079	+3.711	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,654 associations by consensus.

Exploration

CHSY3 survival (RNA) · tumor vs normal (RNA) · all CHSY3 data types