CHST8

Across TCGA patient cohorts, CHST8 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST8-associated genes across cancer lineages are MSH6, mTOR, and INPP4B. Each is linked with CHST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST8-to-partner and partner-to-CHST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CHST8-low versus CHST8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST8→partner) and Y-score (partner→CHST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.439	-3.321	<.001	.009	3	2
UCEC	mTOR →	-0.237	-1.906	<.001	.016	3	2
UCEC	INPP4B →	-0.265	-2.321	.041	.034	3	1
UCEC	mTOR_pS2448 →	-0.147	-3.308	.014	.009	3	1
UCEC	Myosin-IIa_pS1943 →	+0.243	+3.459	.003	.005	3	1
UCEC	Myosin-IIa →	+0.250	+2.122	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MSH6 by CHST8 expression — UCEC

Explore this box plot interactively →