CHST8

Across TCGA cell cohorts, CHST8 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHST8-associated genes across cancer lineages are OR11H6, VWC2L, and RMI1. Each is linked with CHST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST8-to-partner and partner-to-CHST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by CHST8-low versus CHST8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST8→partner) and Y-score (partner→CHST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	2
LUNG_NSCLC_LUAD	VWC2L →	+0.013	+2.465	<.001	.009	3	2
BLOOD_Leukemia	RMI1 →	+0.785	+3.199	.004	.007	3	2
BLOOD_Leukemia	NKX2-6 →	+0.201	+2.979	<.001	.007	3	2
SKIN	PRG3 →	+0.025	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PADI4 →	+0.102	+2.577	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

OR11H6 by CHST8 expression — CNS

Explore this box plot interactively →