CHST3

Across TCGA cell cohorts, CHST3 mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHST3-associated genes across cancer lineages are PRM2, TRIM43B, and OR4C12. Each is linked with CHST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST3-to-partner and partner-to-CHST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM2 grouped by CHST3-low versus CHST3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST3→partner) and Y-score (partner→CHST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRM2 →	+0.028	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	TRIM43B →	+0.034	+3.857	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRAMEF25 →	+0.011	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4E1 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	SPO11 →	+0.030	+3.947	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

PRM2 by CHST3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →