CHRNE

Across TCGA patient cohorts, CHRNE RNA expression is significantly associated with the go_rna of many other GO terms, with 7,137 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHRNE-associated GO terms across cancer lineages are Negative regulation of intrinsic apoptotic signaling pathway, Osteoblast differentiation, and Collagen fibril organization. Each is linked with CHRNE in more than 23 cancer types. Because this analysis shows association rather than direction, both CHRNE-to-partner and partner-to-CHRNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of intrinsic apoptotic signaling pathway grouped by CHRNE-low versus CHRNE-high in KICH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNE→partner) and Y-score (partner→CHRNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	Negative regulation of intrinsic apoptotic signaling pathway →	+0.043	+0.740	<.001	<.001	3	24
ESCA	Osteoblast differentiation →	+0.047	+0.539	<.001	<.001	3	24
ESCA	Collagen fibril organization →	+0.069	+0.453	<.001	<.001	3	24
MESO	Vascular associated smooth muscle cell development →	+0.095	+0.721	<.001	<.001	3	23
SCLC	Response to transforming growth factor beta →	+0.061	+0.574	<.001	<.001	3	23
ESCA	Connective tissue development →	+0.043	+0.546	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,137 associations by consensus.

Negative regulation of intrinsic apoptotic signaling pathway by CHRNE expression — KICH

Explore this box plot interactively →