CHRNE

Across TCGA patient cohorts, CHRNE protein abundance is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHRNE-associated genes across cancer lineages are PDHX, SLC25A12, and VAPB. Each is linked with CHRNE in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNE-to-partner and partner-to-CHRNE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNE versus PDHX in GBM, with a Pearson correlation of 0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNE→partner) and Y-score (partner→CHRNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDHX →	+0.420	+1.470	.003	.007	3	1
GBM	SLC25A12 →	+0.384	+1.470	.007	.007	3	1
GBM	VAPB →	+0.521	+1.470	.008	.007	3	1
GBM	MKKS →	+0.484	+1.470	.002	.007	3	1
GBM	DBT →	+0.664	+1.470	.009	.007	3	1
GBM	RIT2 →	+2.511	+1.470	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

CHRNE vs PDHX — GBM

Explore this scatter interactively →