CHRNE

Across TCGA cell cohorts, CHRNE mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNE-associated genes across cancer lineages are 5-Fluorouracil, 123829, and KRAS (G12C) Inhibitor-12. Each is linked with CHRNE in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNE-to-partner and partner-to-CHRNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5-Fluorouracil grouped by CHRNE-low versus CHRNE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNE→partner) and Y-score (partner→CHRNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	5-Fluorouracil →	+0.620	+2.769	.032	.040	3	1
LARGE_INTESTINE	123829 →	+0.580	+2.649	.047	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.609	+2.646	.013	.047	3	1
LARGE_INTESTINE	CZC24832 →	+0.319	+2.646	.013	.047	1	1
LARGE_INTESTINE	PCI-34051 →	+0.447	+2.646	.019	.047	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.450	+2.649	.022	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

5-Fluorouracil by CHRNE expression — LARGE_INTESTINE

Explore this box plot interactively →