CHRNB4

Across TCGA patient cohorts, CHRNB4 mutation is significantly associated with the RNA expression of many other genes, with 3,521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB4-associated genes across cancer lineages are RNA5SP360, PRAMEF13, and XRRA1. Each is linked with CHRNB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNB4-to-partner and partner-to-CHRNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP360 grouped by CHRNB4-low versus CHRNB4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB4→partner) and Y-score (partner→CHRNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP360 →	+0.040	+3.643	<.001	.009	3	3
LGG	PRAMEF13 →	+0.034	+7.977	<.001	.007	3	2
SKCM	XRRA1 →	+0.390	+2.916	.008	<.001	3	2
SKCM	DHCR7 →	+0.906	+2.097	.005	.003	3	2
UCEC	RPL23AP82 →	+0.458	+1.818	<.001	<.001	3	2
SKCM	MT-TD →	+0.116	+2.312	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,521 associations by consensus.

RNA5SP360 by CHRNB4 expression — SKCM

Explore this box plot interactively →