CHRNB4

Across TCGA pan-cancer cohorts, CHRNB4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CHRNB4 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHRNB4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHRNB4 expression acts as an unfavorable survival marker, although some lineages such as LIHC and THYM show a favorable association.

KIRC, UVM, and ACC are the cancer types where CHRNB4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.557	0.693	<.001	126	view →
UVM	DFS	Tertile	II,III,IV	0.546	0.948	<.001	98	view →
ACC	OS	Median	All	0.440	0.854	<.001	87	view →
UCEC	OS	Median	II,III,IV	0.781	0.912	.002	46	view →
LGG	OS	Median	All	0.735	0.872	<.001	40	view →
LUAD	DFS	Median	All	0.750	0.872	.001	19	view →
LIHC	OS	Median	II,III,IV	0.871	0.655	.005	18	view →
COAD	DFS	Median	II,III,IV	0.380	0.565	.016	15	view →
THYM	OS	Tertile	All	1.000	0.650	.003	14	view →
READ	DFS	Median	III,IV	0.604	0.855	.013	10	view →
KICH	DFS	Median	II,III,IV	0.422	0.928	.009	10	view →
MESO	DFS	Median	III,IV	0.262	0.581	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CHRNB4–KIRC (OS)

Open the KIRC breakdown →