CHRNB4

Across TCGA patient cohorts, CHRNB4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB4-associated genes across cancer lineages are IGFBP2, TFRC, and 14-3-3_beta. Each is linked with CHRNB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB4-to-partner and partner-to-CHRNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by CHRNB4-low versus CHRNB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB4→partner) and Y-score (partner→CHRNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.521	-1.874	.014	.049	3	2
SKCM	TFRC →	+0.541	+2.222	.021	.010	3	2
UCEC	14-3-3_beta →	-0.091	-1.780	.005	.024	3	1
UCEC	EGFR_pY1068 →	-0.237	-1.392	.004	.019	3	1
UCEC	eIF4E →	+0.155	+1.652	.025	.006	3	1
UCEC	eIF4G →	+0.250	+3.169	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

IGFBP2 by CHRNB4 expression — UCEC

Explore this box plot interactively →