CHRNB4

Across TCGA cell cohorts, CHRNB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,676 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CHRNB4-associated GO terms across cancer lineages are Protein K48-linked ubiquitination, Mitochondrial electron transport, cytochrome c to oxygen, and Purine nucleoside triphosphate metabolic process. Each is linked with CHRNB4 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHRNB4-to-partner and partner-to-CHRNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K48-linked ubiquitination grouped by CHRNB4-low versus CHRNB4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB4→partner) and Y-score (partner→CHRNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein K48-linked ubiquitination →	+0.063	+0.254	<.001	<.001	3	8
OESOPHAGUS	Mitochondrial electron transport, cytochrome c to oxygen →	+0.085	+0.683	.006	<.001	3	7
LUNG_NSCLC_LUSC	Purine nucleoside triphosphate metabolic process →	+0.095	+0.595	.001	.004	3	7
LUNG_SCLC	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.078	+1.229	<.001	.006	2	8
OVARY	Regulation of myoblast fusion →	+0.118	+0.260	<.001	<.001	3	7
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.111	+0.248	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,676 associations by consensus.

Protein K48-linked ubiquitination by CHRNB4 expression — OVARY

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