CHRNB3

Across TCGA patient cohorts, CHRNB3 mutation is significantly associated with the RNA expression of many other genes, with 1,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB3-associated genes across cancer lineages are NTF6A, RN7SL612P, and LINC00458. Each is linked with CHRNB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHRNB3-to-partner and partner-to-CHRNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTF6A grouped by CHRNB3-low versus CHRNB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB3→partner) and Y-score (partner→CHRNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NTF6A →	+0.231	+4.090	<.001	.004	3	4
READ	RN7SL612P →	+0.364	+5.219	<.001	.006	3	3
UCEC	LINC00458 →	+0.167	+1.831	.001	.001	3	3
COAD	MIR4802 →	+0.979	+3.276	<.001	.005	3	3
BLCA	MTCO3P45 →	+0.067	+4.788	<.001	.006	3	3
STAD	TTTY13 →	+0.756	+4.372	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,546 associations by consensus.

NTF6A by CHRNB3 expression — STAD

Explore this box plot interactively →