CHRNB3

Across TCGA pan-cancer cohorts, CHRNB3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CHRNB3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHRNB3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHRNB3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KICH, and COAD are the cancer types where CHRNB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHRNB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.015	.007	5	view →
KICH	Female	All	−0.037	.007	4	view →
COAD	All	All	+0.014	.012	2	view →
BRCA	All	II,III,IV	+0.007	.021	2	view →
CHOL	All	All	+0.218	.046	1	view →
LUAD	Male	II,III,IV	+0.083	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CHRNB3–HNSC

Open the HNSC breakdown →