CHRNB3

Across TCGA patient cohorts, CHRNB3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB3-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and JNK_pT183_Y185. Each is linked with CHRNB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNB3-to-partner and partner-to-CHRNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHRNB3-low versus CHRNB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB3→partner) and Y-score (partner→CHRNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.708	+2.087	.001	.005	3	3
UCEC	14-3-3_beta →	-0.118	-3.558	.002	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.190	-3.700	.003	.001	3	2
UCEC	PCNA →	+0.201	+2.700	.015	.006	3	2
UCEC	Annexin-1 →	+0.729	+2.720	<.001	.003	3	2
UCEC	Caspase-8 →	-0.228	-1.678	.018	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by CHRNB3 expression — UCEC

Explore this box plot interactively →