CHRNB3

Across TCGA cell cohorts, CHRNB3 mutation is significantly associated with the RNA expression of many other genes, with 463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNB3-associated genes across cancer lineages are PRKCQ, CRYBB1, and MIOX. Each is linked with CHRNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB3-to-partner and partner-to-CHRNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCQ grouped by CHRNB3-low versus CHRNB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB3→partner) and Y-score (partner→CHRNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRKCQ →	+0.829	+3.064	.001	.009	3	2
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	1
LARGE_INTESTINE	MIOX →	+0.291	+3.364	<.001	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.576	+3.364	.003	.002	3	1
LARGE_INTESTINE	PSMA7 →	-0.481	-3.106	.005	.007	3	1
LARGE_INTESTINE	MTFMT →	+0.586	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 463 associations by consensus.

PRKCQ by CHRNB3 expression — LARGE_INTESTINE

Explore this box plot interactively →