CHRNB3

Across TCGA cell cohorts, CHRNB3 mutation is significantly associated with the mutation status of many other genes, with 5,413 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNB3-associated genes across cancer lineages are ESPL1, KDM5A, and PPP1R26. Each is linked with CHRNB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNB3-to-partner and partner-to-CHRNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESPL1 grouped by CHRNB3-low versus CHRNB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB3→partner) and Y-score (partner→CHRNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESPL1 →	+2.906	+3.510	<.001	<.001	1	5
LUNG_SCLC	KDM5A →	+5.502	+5.502	.003	.003	1	4
BLOOD_Leukemia	PPP1R26 →	+2.975	+3.794	.006	.006	1	4
LARGE_INTESTINE	ZNF318 →	+2.836	+4.015	<.001	<.001	1	4
LARGE_INTESTINE	KIAA1549 →	+1.321	+2.321	.006	.006	1	4
LUNG_SCLC	EPB41L1 →	+4.502	+5.066	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,413 associations by consensus.

ESPL1 by CHRNB3 expression — LARGE_INTESTINE

Explore this box plot interactively →