CHRNB2

Across TCGA patient cohorts, CHRNB2 mutation is significantly associated with the RNA expression of many other genes, with 1,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB2-associated genes across cancer lineages are ACTBP7, SNORD126, and RN7SL447P. Each is linked with CHRNB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNB2-to-partner and partner-to-CHRNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTBP7 grouped by CHRNB2-low versus CHRNB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB2→partner) and Y-score (partner→CHRNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTBP7 →	+0.448	+2.055	<.001	.005	3	3
UCEC	SNORD126 →	+0.288	+1.916	.001	.009	3	3
UCEC	RN7SL447P →	+0.179	+1.916	<.001	.009	3	3
STAD	TAS2R8 →	+0.262	+3.787	<.001	.005	3	3
BRCA	RNA5SP361 →	+0.193	+4.986	<.001	.003	3	3
UCEC	TXN2 →	+0.342	+2.833	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,766 associations by consensus.

ACTBP7 by CHRNB2 expression — UCEC

Explore this box plot interactively →