CHRNB2

Across TCGA patient cohorts, CHRNB2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB2-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and GAPDH. Each is linked with CHRNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB2-to-partner and partner-to-CHRNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CHRNB2-low versus CHRNB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB2→partner) and Y-score (partner→CHRNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.138	-3.432	<.001	.005	3	2
UCEC	eIF4G →	+0.297	+1.807	.020	.027	3	2
UCEC	GAPDH →	+0.505	+1.807	.022	.027	3	2
UCEC	p62 Lck ligand →	+0.348	+2.469	.009	.010	3	2
UCEC	S6_pS240_S244 →	+0.532	+2.321	.001	.006	3	2
UCEC	c-Kit →	-0.193	-3.150	.045	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

14-3-3_beta by CHRNB2 expression — UCEC

Explore this box plot interactively →