CHRNB2

Across TCGA cell cohorts, CHRNB2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNB2-associated genes across cancer lineages are NEUROG3, H1-8, and OR52B4. Each is linked with CHRNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB2-to-partner and partner-to-CHRNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG3 grouped by CHRNB2-low versus CHRNB2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB2→partner) and Y-score (partner→CHRNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEUROG3 →	+0.006	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	H1-8 →	+0.033	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52B4 →	+0.019	+5.662	<.001	.002	3	1
BREAST	DEFB134 →	+0.242	+4.199	<.001	.007	3	1
LARGE_INTESTINE	PADI4 →	+0.073	+3.464	.002	.004	3	1
LARGE_INTESTINE	HIPK4 →	+0.073	+3.301	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

NEUROG3 by CHRNB2 expression — URINARY_TRACT

Explore this box plot interactively →