CHRNA5

Across TCGA patient cohorts, CHRNA5 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,870 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHRNA5-associated proteins across cancer lineages are MCM2, MCM3, and MCM7. Each is linked with CHRNA5 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHRNA5-to-partner and partner-to-CHRNA5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA5 versus MCM2 in OV, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA5→partner) and Y-score (partner→CHRNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MCM2 →	+0.609	+0.734	.003	.001	3	8
OV	MCM3 →	+0.794	+0.705	.001	<.001	3	8
OV	MCM7 →	+0.655	+0.753	.003	.001	3	8
OV	NCAPD2 →	+0.570	+0.714	<.001	.001	3	8
OV	FEN1 →	+0.500	+0.596	<.001	.003	3	8
GBM	SMC2 →	+0.633	+0.316	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,870 associations by consensus.

CHRNA5 vs MCM2 — OV

Explore this scatter interactively →