CHRNA4

Across TCGA patient cohorts, CHRNA4 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,166 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHRNA4-associated proteins across cancer lineages are NCF4, PARP12, and PARP14. Each is linked with CHRNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA4-to-partner and partner-to-CHRNA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA4 versus NCF4 in GBM, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA4→partner) and Y-score (partner→CHRNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF4 →	-0.487	-0.575	<.001	<.001	3	2
GBM	PARP12 →	-0.394	-0.711	<.001	<.001	3	2
GBM	PARP14 →	-0.394	-0.676	<.001	<.001	3	2
GBM	PARP9 →	-0.342	-0.610	.002	.002	3	2
GBM	TYMP →	-0.538	-0.441	<.001	.003	3	2
GBM	VAV1 →	-0.400	-0.449	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

CHRNA4 vs NCF4 — GBM

Explore this scatter interactively →