CHRNA3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CHRNA3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA3-associated genes across cancer lineages are GPR161, ARHGAP39, and MIR185. Each is linked with CHRNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA3 versus GPR161 in PDAC, with a Pearson correlation of -0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACGPR161 →-1.188-0.730.002.00532
LUADARHGAP39 →-0.780-0.572.002<.00132
PDACMIR185 →-1.467-0.665.003.00132
PDACHAS2-AS1 →-0.442-0.780.005.00132
LSCCPLCB2 →-1.427-1.542.001.00632
LUADHIGD1AP16 →-1.343-0.673<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,983 associations by consensus.

CHRNA3 vs GPR161 — PDAC

Per-sample scatter of CHRNA3 vs GPR161 in PDAC (Pearson r = -0.81).

Explore this scatter interactively →

Exploration