CHRNA1

Across TCGA patient cohorts, CHRNA1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,301 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHRNA1-associated genes across cancer lineages are CPEB1-AS1, SLC4A3, and TRIM46. Each is linked with CHRNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA1-to-partner and partner-to-CHRNA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA1 versus CPEB1-AS1 in GBM, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA1→partner) and Y-score (partner→CHRNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CPEB1-AS1 →	-0.298	-0.392	.003	.001	3	2
LSCC	SLC4A3 →	-1.174	-0.612	<.001	<.001	3	2
UCEC	TRIM46 →	-0.972	-0.352	.001	.004	3	2
UCEC	ZNRF3-AS1 →	-1.094	-0.344	.005	.001	3	2
LSCC	SS18L1 →	-0.448	-0.540	.007	<.001	3	2
UCEC	RNU6-371P →	-1.704	-0.307	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,301 associations by consensus.

CHRNA1 vs CPEB1-AS1 — GBM

Explore this scatter interactively →