CHRNA1

Across TCGA pan-cancer cohorts, CHRNA1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CHRNA1 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHRNA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHRNA1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

ACC, LUAD, and KIRC are the cancer types where CHRNA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.707	0.949	<.001	89	view →
LUAD	OS	Median	III,IV	0.667	0.320	<.001	57	view →
KIRC	OS	Median	II,III,IV	0.675	0.432	<.001	52	view →
LGG	OS	Median	All	0.725	0.898	<.001	51	view →
KIRP	DFS	Median	All	0.922	0.787	<.001	48	view →
THYM	DFS	Median	All	0.827	0.971	<.001	46	view →
HNSC	OS	Median	All	0.707	0.826	.001	36	view →
COAD	OS	Median	II,III,IV	0.845	0.716	.003	31	view →
SARC	OS	Quartile	All	0.612	0.847	<.001	25	view →
DLBC	DFS	Quartile	III,IV	1.000	0.330	.008	25	view →
SCLC	OS	Median	All	1.000	0.604	.009	21	view →
UCS	DFS	Quartile	III,IV	0.605	0.202	.030	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CHRNA1–ACC (OS)

Open the ACC breakdown →