CHRNA1

Across TCGA patient cohorts, CHRNA1 mutation is significantly associated with the RNA expression of many other genes, with 1,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA1-associated genes across cancer lineages are SNORD126, LINC01151, and MIR4662B. Each is linked with CHRNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA1-to-partner and partner-to-CHRNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD126 grouped by CHRNA1-low versus CHRNA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA1→partner) and Y-score (partner→CHRNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD126 →	+0.196	+2.493	.001	.001	3	2
UCEC	LINC01151 →	+0.610	+1.628	<.001	.006	3	2
BLCA	MIR4662B →	+0.606	+5.329	<.001	.006	3	2
UCEC	TMEM200C →	-0.436	-1.904	.009	.005	3	2
UCEC	IGHV2-26 →	+1.228	+2.008	.005	.005	3	2
UCEC	EMC1-AS1 →	+0.549	+1.947	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,834 associations by consensus.

SNORD126 by CHRNA1 expression — SKCM

Explore this box plot interactively →