CHRNA1

Across TCGA cell cohorts, CHRNA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,926 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CHRNA1-associated GO terms across cancer lineages are Positive regulation of DNA-templated transcription initiation, Regulation of mRNA processing, and Regulation of synapse structural plasticity. Each is linked with CHRNA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNA1-to-partner and partner-to-CHRNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated transcription initiation grouped by CHRNA1-low versus CHRNA1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA1→partner) and Y-score (partner→CHRNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA-templated transcription initiation →	+0.059	+0.044	<.001	<.001	3	5
SOFT_TISSUE	Regulation of mRNA processing →	+0.091	+3.985	<.001	.002	3	4
SOFT_TISSUE	Regulation of synapse structural plasticity →	-0.798	-3.345	.001	<.001	3	4
SOFT_TISSUE	Positive regulation of transcription initiation by RNA polymerase II →	+0.057	+2.794	<.001	.006	3	4
LIVER	DNA-templated transcription initiation →	+0.059	+0.194	.002	.009	3	4
SOFT_TISSUE	Translational elongation →	+0.044	+2.951	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,926 associations by consensus.

Positive regulation of DNA-templated transcription initiation by CHRNA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →