CHRNA1

Across TCGA cell cohorts, CHRNA1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CHRNA1-associated genes across cancer lineages are DCD, PRSS58, and KRTAP4-3. Each is linked with CHRNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA1-to-partner and partner-to-CHRNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by CHRNA1-low versus CHRNA1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA1→partner) and Y-score (partner→CHRNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCD →	+0.068	+4.977	.001	.007	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	KRTAP4-3 →	+0.023	+5.357	<.001	.003	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MBD3L2 →	+0.151	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DCD by CHRNA1 expression — SKIN

Explore this box plot interactively →