Across TCGA patient cohorts, CHRM5 mutation is significantly associated with the RNA expression of many other genes, with 3,272 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRM5-associated genes across cancer lineages are RNA5SP21, MAPKAPK5-AS1, and LDHAP7. Each is linked with CHRM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRM5-to-partner and partner-to-CHRM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM5→partner) and Y-score (partner→CHRM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP21 →	+0.496	+1.675	.003	.004	3	3
UCEC	MAPKAPK5-AS1 →	+0.395	+2.040	<.001	.005	3	2
SKCM	LDHAP7 →	+0.807	+2.328	.004	.003	3	2
UCEC	RPL32P32 →	+0.534	+1.885	<.001	.003	3	2
SKCM	ARFGAP3 →	+0.633	+3.350	.001	.005	3	2
SKCM	UBL7-AS1 →	+0.397	+3.019	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,272 associations by consensus.

Exploration

CHRM5 survival (RNA) · tumor vs normal (RNA) · all CHRM5 data types