Across TCGA pan-cancer cohorts, CHRM5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHRM5’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where CHRM5 RNA is repressed in tumor relative to normal tissue. In most cancer types CHRM5 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.
COAD, HNSC, and KICH are the cancer types where CHRM5 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHRM5 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.