Across TCGA patient cohorts, CHRM5 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRM5-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with CHRM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRM5-to-partner and partner-to-CHRM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM5→partner) and Y-score (partner→CHRM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.615	+2.321	.026	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.571	+1.697	.004	.012	3	3
UCEC	Cyclin-B1 →	+0.727	+2.906	<.001	.001	3	2
UCEC	FoxM1 →	+0.197	+1.247	.025	.045	3	2
UCEC	PDCD4 →	-0.482	-2.312	.002	.005	3	2
UCEC	Annexin-1 →	+0.538	+2.434	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

CHRM5 survival (RNA) · tumor vs normal (RNA) · all CHRM5 data types