Across TCGA cell cohorts, CHRM5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CHRM5-associated genes across cancer lineages are IL36B, DEFB4A, and OR4X2. Each is linked with CHRM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRM5-to-partner and partner-to-CHRM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM5→partner) and Y-score (partner→CHRM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL36B →	+0.096	+3.695	.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB4A →	+0.452	+3.882	.007	.003	3	1
LUNG_NSCLC_LUAD	OR4X2 →	+0.020	+4.362	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR1G1 →	+0.028	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.039	+3.887	<.001	.002	3	1
LUNG_NSCLC_LUAD	CCL18 →	+0.026	+3.628	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

CHRM5 survival (RNA) · tumor vs normal (RNA) · all CHRM5 data types