CHRM4

Across TCGA patient cohorts, CHRM4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,084 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHRM4-associated genes across cancer lineages are GRK3, SEZ6L, and SNU13. Each is linked with CHRM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRM4-to-partner and partner-to-CHRM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRM4 versus GRK3 in GBM, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM4→partner) and Y-score (partner→CHRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRK3 →	+0.500	+0.577	.005	<.001	3	1
GBM	SEZ6L →	+1.538	+0.344	<.001	.004	3	1
GBM	SNU13 →	+0.298	+0.402	.005	.006	3	1
GBM	SOX10 →	+1.880	+0.434	<.001	.001	3	1
GBM	SLC16A8 →	+0.742	+0.625	<.001	<.001	3	1
GBM	TCF20 →	+0.289	+0.349	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,084 associations by consensus.

CHRM4 vs GRK3 — GBM

Explore this scatter interactively →