CHRM4

Across TCGA patient cohorts, CHRM4 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRM4-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and Rad50. Each is linked with CHRM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRM4-to-partner and partner-to-CHRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHRM4-low versus CHRM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM4→partner) and Y-score (partner→CHRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.600	+1.505	.004	.034	3	3
UCEC	MSH2 →	-0.299	-2.433	<.001	.018	3	2
COAD	Rad50 →	-0.386	-2.991	.001	.036	2	3
SKCM	EGFR →	-0.184	-3.321	.029	.010	3	2
UCEC	JNK2 →	+0.223	+3.196	.001	.009	3	2
UCEC	beta-Catenin →	+0.382	+1.874	.033	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by CHRM4 expression — UCEC

Explore this box plot interactively →