CHRM4

Across TCGA cell cohorts, CHRM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,705 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CHRM4-associated GO terms across cancer lineages are Response to starvation, Mitochondrial electron transport, cytochrome c to oxygen, and Response to mitochondrial depolarisation. Each is linked with CHRM4 in more than 10 cancer types. Because this analysis shows association rather than direction, both CHRM4-to-partner and partner-to-CHRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to starvation grouped by CHRM4-low versus CHRM4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM4→partner) and Y-score (partner→CHRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.065	+0.297	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Mitochondrial electron transport, cytochrome c to oxygen →	+0.091	+0.222	<.001	.005	3	10
STOMACH	Response to mitochondrial depolarisation →	+0.111	+1.109	.005	.009	3	10
UPPER_AERODIGESTIVE_TRACT	Cellular response to starvation →	+0.060	+0.307	<.001	<.001	3	9
BREAST	Transcription initiation at RNA polymerase II promoter →	+0.086	+0.613	<.001	.002	3	9
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.055	+0.684	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,705 associations by consensus.

Response to starvation by CHRM4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →