CHRM4

Across TCGA cell cohorts, CHRM4 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRM4-associated genes across cancer lineages are OR10R2, GFRA4, and FBXO39. Each is linked with CHRM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRM4-to-partner and partner-to-CHRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by CHRM4-low versus CHRM4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM4→partner) and Y-score (partner→CHRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.484	+3.551	<.001	.009	3	2
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	2
LARGE_INTESTINE	FBXO39 →	+0.153	+3.906	.006	.002	3	2
LUNG_SCLC	KRTAP4-9 →	+0.284	+4.044	<.001	.009	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	DIRAS2 →	+0.101	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR10R2 by CHRM4 expression — BLOOD_Leukemia

Explore this box plot interactively →