CHRM3-AS1

Across TCGA pan-cancer cohorts, CHRM3-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CHRM3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CHRM3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CHRM3-AS1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where CHRM3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHRM3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−1.365	<.001	10	view →
KICH	All	II,III,IV	−0.899	<.001	7	view →
HNSC	Male	III,IV	+0.120	.001	7	view →
LUSC	All	All	+0.117	.001	5	view →
UCEC	All	II,III,IV	−0.177	.008	4	view →
PRAD	All	All	+0.124	.001	2	view →
BLCA	Male	IV	+0.272	.049	1	view →
KIRC	All	All	−0.226	.048	1	view →
LUSC	Male	III,IV	−0.110	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

CHRM3-AS1–KIRP

Open the KIRP breakdown →