CHRFAM7A

Across TCGA patient cohorts, CHRFAM7A mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRFAM7A-associated genes across cancer lineages are RNU6-1138P, CHCHD3P1, and RNU6-737P. Each is linked with CHRFAM7A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRFAM7A-to-partner and partner-to-CHRFAM7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1138P grouped by CHRFAM7A-low versus CHRFAM7A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRFAM7A→partner) and Y-score (partner→CHRFAM7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1138P →	+0.479	+5.790	<.001	.003	3	2
SKCM	CHCHD3P1 →	+0.101	+4.603	.009	.001	3	2
UCEC	RNU6-737P →	+0.347	+4.137	<.001	.008	3	2
UCEC	RNU6-1261P →	+0.266	+4.464	<.001	.005	3	2
UCEC	OR10AE1P →	+0.133	+3.198	<.001	.009	3	2
SKCM	RN7SL680P →	+0.195	+5.634	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

RNU6-1138P by CHRFAM7A expression — COAD

Explore this box plot interactively →