CHRDL2

Across TCGA patient cohorts, CHRDL2 mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CHRDL2-associated genes across cancer lineages are MIR15B, TRAJ4, and LINC02574. Each is linked with CHRDL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRDL2-to-partner and partner-to-CHRDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR15B grouped by CHRDL2-low versus CHRDL2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRDL2→partner) and Y-score (partner→CHRDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR15B →	+0.293	+5.678	<.001	.003	3	2
UCEC	TRAJ4 →	+0.757	+3.026	.001	.002	3	2
COAD	LINC02574 →	+0.369	+3.740	<.001	.002	3	2
UCEC	KIR3DL2 →	+0.203	+3.313	.003	.009	3	2
BLCA	RNA5SP45 →	+0.303	+7.640	<.001	.009	3	2
SARC	RN7SL764P →	+0.182	+5.778	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

MIR15B by CHRDL2 expression — STAD

Explore this box plot interactively →