CHRDL2

Across TCGA pan-cancer cohorts, CHRDL2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CHRDL2 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CHRDL2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHRDL2 expression acts as an unfavorable survival marker, although some lineages such as READ and HNSC show a favorable association.

KIRP, KICH, and BLCA are the cancer types where CHRDL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.475	0.820	<.001	79	view →
KICH	DFS	Tertile	II,III,IV	0.408	0.871	.004	58	view →
BLCA	DFS	Median	II,III,IV	0.276	0.434	.003	58	view →
ACC	DFS	Quartile	II,III,IV	0.094	0.773	.003	33	view →
LUSC	DFS	Quartile	All	0.294	0.526	<.001	22	view →
THYM	DFS	Tertile	All	0.631	0.875	.005	21	view →
READ	DFS	Tertile	IV	0.883	0.348	.009	10	view →
HNSC	DFS	Tertile	IV	0.779	0.577	.005	9	view →
SARC	OS	Tertile	All	0.912	0.801	.016	8	view →
KIRC	DFS	Tertile	All	0.559	0.679	.015	7	view →
MESO	DFS	Median	IV	0.488	0.164	.001	6	view →
TGCT	DFS	Median	All	0.770	0.889	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CHRDL2–KIRP (OS)

Open the KIRP breakdown →