CHRDL2

Across TCGA patient cohorts, CHRDL2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CHRDL2-associated genes across cancer lineages are Caspase-7-cleavedD198, HER3_pY1289, and PREX1. Each is linked with CHRDL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRDL2-to-partner and partner-to-CHRDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHRDL2-low versus CHRDL2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRDL2→partner) and Y-score (partner→CHRDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.163	+2.815	.007	.036	3	3
SKCM	HER3_pY1289 →	-0.112	-2.442	.013	.020	3	1
COAD	PREX1 →	+0.280	+2.832	.014	.035	3	1
UCEC	Myosin-IIa →	+0.225	+2.814	.047	.036	1	1
COAD	Lck →	+0.392	+2.832	.019	.035	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-7-cleavedD198 by CHRDL2 expression — COAD

Explore this box plot interactively →