CHRDL2

Across TCGA cell cohorts, CHRDL2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHRDL2-associated genes across cancer lineages are MMP20, C1orf158, and XCR1. Each is linked with CHRDL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRDL2-to-partner and partner-to-CHRDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP20 grouped by CHRDL2-low versus CHRDL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRDL2→partner) and Y-score (partner→CHRDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP20 →	+0.075	+3.453	<.001	.009	3	1
SKIN	C1orf158 →	+0.044	+3.510	<.001	.003	3	1
SKIN	XCR1 →	+0.135	+3.688	<.001	.002	3	1
SKIN	BPIFB3 →	+0.015	+4.022	<.001	.006	3	1
SKIN	MYH6 →	+0.012	+3.632	<.001	.003	3	1
SKIN	OR4A47 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MMP20 by CHRDL2 expression — SKIN

Explore this box plot interactively →