CHRD

Across TCGA patient cohorts, CHRD mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CHRD-associated genes across cancer lineages are ATM, EGFR_pY1068, and mTOR_pS2448. Each is linked with CHRD in more than 3 cancer types. Because this analysis shows association rather than direction, both CHRD-to-partner and partner-to-CHRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CHRD-low versus CHRD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRD→partner) and Y-score (partner→CHRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.716	-2.643	<.001	<.001	3	4
COAD	EGFR_pY1068 →	-0.403	-3.169	.003	.017	3	3
COAD	mTOR_pS2448 →	-0.241	-2.982	.001	.034	3	3
COAD	Akt →	-0.657	-1.874	<.001	.049	3	3
COAD	PKC-b-II_pS660 →	-0.544	-3.459	<.001	.004	3	3
COAD	beta-Catenin →	-1.059	-2.576	<.001	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ATM by CHRD expression — UCEC

Explore this box plot interactively →