CHRD

Across TCGA cell cohorts, CHRD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRD-associated GO terms across cancer lineages are Potassium ion import across plasma membrane, Regulation of potassium ion transport, and Protein-DNA complex organization. Each is linked with CHRD in more than 11 cancer types. Because this analysis shows association rather than direction, both CHRD-to-partner and partner-to-CHRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Potassium ion import across plasma membrane grouped by CHRD-low versus CHRD-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRD→partner) and Y-score (partner→CHRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Potassium ion import across plasma membrane →	-0.259	-1.455	<.001	<.001	3	12
LIVER	Regulation of potassium ion transport →	-0.155	-2.053	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Protein-DNA complex organization →	+0.053	+0.748	.004	.001	3	10
OESOPHAGUS	Establishment of protein localization to organelle →	+0.071	+1.185	<.001	<.001	3	10
OESOPHAGUS	Positive regulation of monoatomic ion transport →	-0.087	-1.155	<.001	.002	3	10
LIVER	Positive regulation of DNA repair →	+0.070	+2.513	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

Potassium ion import across plasma membrane by CHRD expression — OESOPHAGUS

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